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Thursday, August 28, 2003

The Secret of a Longer Life

This is certainly good news. I'm off to the Bulgarian restaurant here tonight, and this is the best excuse I've seen recently for having a 'nice glass of red'. No Bulgarian Cabernet Sauvignan on the wine list unfortunately, but the local Spanish red - Castillo de Enguera - as furnished by the Bulgarian manager of the wine 'cave', is very acceptable. In fact the restaurant seems to be the place to hang out for the 'old hands', those who have been here over five years, and have risen to form an integral part of the local 'new technocratic elite'. Tomorrow night it's a Rakia evening with some of the less fortunate new arrivals who spend the day picking peppers in the heat of the mid-day sun. This is hardly to be recommened on health grounds. Nor is the shopska salata and purzheni kartofi sus sirene which tend to accompany the ritual. The latter dish is essentially chips under a layer of grated cheese. It is however, very very nice.

An ingredient of red wine extends lifespan by up to 70% - in yeast1. The compound seems to mimic the age-enhancing effects of calorie restriction on the single-celled organism.

Capitalizing on the chemical, called resveratrol, is a long way off in humans, says David Sinclair of Harvard Medical School in Boston, Massachusetts, who led the research. To match the yeast doses, he says, humans would need to drink a glass of their favourite vintage morning, noon and night.

But the research may help explain why red-quaffing Mediterraneans live to a ripe old age. Resveratrol boosts levels of an enzyme called Sir2, which is thought to extend lifespan by stabilizing DNA. "It's highly plausible that boosting enzyme activity will slow functional decline in old age," agrees Peter Piper, who studies ageing at University College London.

Resveratrol is one of a group of chemicals called polyphenols. Previous research has suggested that these can protect against heart disease and osteoporosis in humans. "It may not be just a longer life - it may also be a healthier one," says Sinclair. The compound is one of 17 plant molecules so far found to extend life in baker's yeast (Saccharomyces cerevisiae). Resveratrol also gives fruitflies, which typically live for around a month, an extra ten days of life, says Sinclair. Studies on mice are in the pipeline. Sinclair gave his yeast fresh grape extract. Normally, the organism divides around 25 times and then dies. Resveratrol-treated yeast underwent an extra 15 replications. Many polyphenols are also found in tea, fruit and vegetables, says Piper. "It stresses the importance of eating a healthy, balanced diet," he says. Pharmacologists are also developing a stable, slow-release resveratrol pill.
Source: Nature

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